NOT DECREASING OF LEFT VENTRICULAR FUNCTION AFTER LONG TIME IN PATIENION TS WITH STEMS CELLS IMPLANTED AFTER ACUTE MYOCARDIAL INFARCT
Author Block R. J. Fernandez Vina 1 , J. Saslavsky 2 , R. Fernandez Viña 3 , O. Andrin 1 , F. Vrsalovick 4 , N. Muttis 1 , S. Murad Neto 5 , D. Dudoblisnky 6 , J. Tuma 7 , R. De Mouras 8 , P. Andres 1 , L. Camozzi 9 , C. D Adamo 10 , F. Benetti 11 , M. Fernandez Viña 12 ;
1 San Nicolas Clinic FernandezVina Foundation, San Nicolas (Buenos Aires), ARGENTINA, 2 Universidad Nacional de Rosario, Rosario, ARGENTINA, 3 Universidad Maimonides Buenos Aires, Buenos Aires), ARGENTINA, 4 San Nicolas Clinic Interventional Cardiology, San Nicolas (Buenos Aires), ARGENTINA, 5 Instituto de pos Graduacion de Univ. Rio de Janeiro, Rio de Janeiro, BRAZIL, 6 Universidad Medicina Rosario Argentina, Rosario, ARGENTINA, 7 Clinica San Felipe Peru, Lima, PERU, 8 Instituto de pos Graduacion de Univ. Rio de Janeiro, Rosario, BRAZIL, 9 Fernandez Viña Foundation SAEGRE, San Nicolas (Buenos Aires), ARGENTINA, 10 San Nicolas Clinic Chief Internal Medicne, San Nicolas (Buenos Aires), ARGENTINA, 11 San Nicolas Clinic Benetti Foundation, Buenos Aires), ARGENTINA, 12 MD Anderson Medical Center, Houston, TX.
Objectives : To evaluate the long time performance of the Left Ventricular function of Acute Myocardial Infarction treated with Stems cells implant.
Method : 32 patients that suffered AMI were treated with primary PTCA with Stents. The Ventriculography Fraction Ejection oscillated between the 21 and 32%. Between the 7 and 12 days after AMI were implanted through the artery and with occlusion of the Coronary Sinus Veined, autologuous mononucleares cells CD 34(+) and CD38 (-) in a quantity average of 22x10p6. Results: It was done after 180 days a coronariography and ventriculography and were observed permeability of all the Stents and an improvement of the FEj of until 76% in all the patients in relationship to the basal FEj. The patients were controlled during one period up to 2 years and its was verified by echocardiogram that deterioration of the contractile function didn't take place and there was not MACE, existing a single non related death. This group was compared with a Control Group of 26 patients that suffered a similarly characteristics AMI and that were subjected alone with PTCA and Stent and it was observed an increment of the FEj of 35% in relationship with the basal FEj. After 180 days of the acute episode it was objetived 23% of reestenosis of the Stents and in a 2 years period after, episodes of MACE were verified in 35% of the patients and had a mortality of 3 patients (1,10%) and it was verified a lost of the FEy.de 16% in relationship of the control Ventriculography done after 180 days . Conclusions : The implant of Mononucleares bone marrow Cells (Stems Cells) after the AMI improves the performance of the VI which is maintained in the time (2 years) and it seemed to avoid the Coronary Stent reestenosis at least in immediate form.